Laboratory of Molecular Pharmacology
Members: CHANG Kwenjen (PI), SHEN Yuehai, WANG Guanlin
Office: Room B-419
Phone: (86) 871-65920747
Laboratory of Molecular Pharmacology (LMP) aims to discover novel therapies for human diseases, with a joint effort of molecular pharmacologists and synthetic chemists. To achieve this goal, we are working on the molecular biology of cancer and addiction, and on the chemical synthesis of potential drugs.
Current projects include: 1) discovery of novel anticancer agent without toxicity to normal cells, based on TRAIL-mediated apoptosis mechanism; 2) structure optimization of anticancer ansamycin natural products, by developing total synthesis for faster preparation of analogs; 3) the mechanism of opiate receptors and design of novel ligands for development of pain killer without unwanted side effect such as addiction and respiratory depression.
(by SHEN Yuehai)