Head of Center for pharmacy
G protein couple receptor signaling and EGF receptor signaling; Drug screening based on intramolecular FRET sensors with research fund of 13 million RMB
Preside over project “Screening tranquilizing components from Chinese medicines using temporal change of G protein coupled receptor as an indicator” （funded by National Natural Science Foundation of China, 0.73 million RMB）
Preside over project “Systematic identification of RAF kinase interactomes and its roles in lung carcinogenesis.”（funded by National Natural Science Foundation of China, 2.1 million RMB）
Preside over project “Screening natural chemical with sedative and weight lose effect using intramolecular FRET sensor of Orexin receptor” (Funded by Highend talent program of Yunnan province, 7.3 million RMB)
May 2012-present, Professor, Faculty of Bioscience and technology, Kunming University of Science and Technology.
April 2005-April 2012, Research associate, Molecular pharmacology and Proteomics group, Faculty of Biomedical and Life Sciences, University of Glasgow, UK
Dec. 2002-Mar. 2005, Postdoctoral Researcher, Department of Biology, University of York, UK
Dec. 2000-Dec. 2002, Postdoctoral Research Fellow, Atherosclerosis Laboratory, Department of Biochemistry and Medial Genetics, University of Manitoba, Canada
Aug. 1999-Dec. 2000, Assistant Professor. Toxicological Laboratory, Kunming Institute of Zoology, Chinese Academy of Sciences. Kunming, Yunnan, China
Sep. 1995—Aug. 1999, Ph.D. Toxicological Laboratory, Kunming Institute of Zoology, Chinese Academy of Sciences, Kunming, Yunnan, China.
Sep. 1992—Jul. 1995, M. Sc. The Department of Biology, Sichuan University, Chengdu, Sichuang, China.
Sep. 1986—Jul. 1990, B. Sc. The Department of Biology, Sichuan University, Chengdu, Sichuang, China.
Selected 10 papers in recent years
1.Tian-Rui Xu, Vladislav Vyshemirsky, Amélie Gormand, Alex von Kriegsheim, Mark Girolami, George S Baillie, Dominic Ketley, Allan J Dunlop, Graeme Milligan, Miles D Houslay, Walter Kolch (2010) Inferring Signaling Pathway Topologies from Multiple Perturbation Measurements of Specific Biochemical Species. Science signaling. 3, ra20 (1-10). (Presented as a cover article).
2.Tian-Rui Xu, Ruifang Lu, David Romano, Andrew Pitt, Miles Houslay, Graeme Milligan, and Walter Kolch (2012) Eukaryotic translation initiation factor 3, subunit a, regulates the extracellular signal-regulated kinase pathway. Molecular and Cellular Biology. 32, 88-95.
3.Tian-Rui Xu, Richard J. Ward, John D. Pediani and Graeme Milligan (2012) Intramolecular fluorescence resonance energy transfer (FRET) sensors of the orexin OX1 and OX2 receptors identify slow kinetics of agonist activation. Journal Biological Chemistry. 287, 14937-14949.
4.Tian-Rui Xu, Richard J. Ward, John D. Pediani and Graeme Milligan (2011) The orexin OX1 receptor exists predominantly as a homo-dimer in the basal state: Potential regulation of receptor organisation by both agonist and antagonist ligands. Biochemical journal. 439, 171-183.
5.Tian-Rui Xu, George S. Baillie, Narinder Bhari, Thomas Houslay, Andrew M. Pitt, David R. Adams, Walter Kolch, Miles D. Houslay and Graeme Milligan (2008) Mutations of b-arrestin 2 that limit self-association also interfere with interactions with the b2-adrenoceptor and the ERK1/2 MAP kinases Implications for b2-adrenoceptor-signalling via the ERK1/2 MAP kinases. Biochemical journal 413, 51-60.
6.Tian-Rui Xu*, Yang Yang , Richard Ward , Linghuan Gao , Ying Liu (2013) Orexin receptors: Multi-functional therapeutic targets for sleeping disorders, eating disorders, drug addiction, cancers and other physiological disorders. Cellular Signalling 25, 2413-2423.
7.Su An, Yang Yang, Richard Ward, Ying Liu, Xiao-Xi Guo, Tian-Rui Xu* (2015) A-Raf: A new star of the family of raf kinases. Critical Reviews in Biochemistry and Molecular Biology. 50, 520-531.
8.Ying Liu, Su An, Richard Ward, Yang Yang, Xiao-Xi Guo, Wei Li*, Tian-Rui Xu* (2016) G protein-coupled receptors as promising cancer targets. Cancer letters. 376, 226-239.
9.Ying Liu, Yang Yang, Richard Ward, Su An, Xiao-Xi Guo, Wei Li* and Tian-Rui Xu* (2015) Biased signalling: the instinctive skill of the cell in the selection of appropriate signalling pathways. Biochemical journal. 470, 155-167.
10.Su An, Yang Yang, Richard Ward, Ying Liu, Xiao-Xi Guo, Tian-Rui Xu* (2015) RAF-interactome in tuning the complexity and diversity of RAF Function. FEBS Journal 282, 32-53.